Contractile Characteristics of Rat Mesenteric Artery after Organ Culture
نویسندگان
چکیده
منابع مشابه
Mechanisms Underlying a Decrease in KCl-Induced Contraction after Long-Term Serum-Free Organ Culture of Rat Isolated Mesenteric Artery
Organ culture of blood vessel is a better technique to investigate the long-term effects of drugs. However, some functional changes may occur from freshly isolated vessel (Fresh). Mammalian/mechanistic target of rapamycin (mTOR) regulates smooth muscle differentiation and Ca(2+) mobilization. We thus investigated mechanisms of alteration in smooth muscle contractility after serum-free organ cul...
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The aim of this study was to explore the changes evoked by organ culture in the signalling pathways activated by noradrenaline in rat resistance mesenteric artery. Contractile responses and calcium signalling were significantly more sensitive to noradrenaline in arteries cultured for 48-72 h in the absence of growth factors compared to fresh arteries. Both calcium release activated by noradrena...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2010
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.10-0205